HCN2 rescues brain defects by enforcing endogenous voltage pre-patterns: Computationally modeling embryonic bioelectrics.

Pai, V. P., Peitak, A., Willocq V., Ye. B., Shi N-Q., and Levin, M

Nature Communication 2018 Mar 8;9(1):998

​

The brain is required for normal muscle and nerve patterning during early Xenopus development.

Herrera-Rincon, C., Pai, V. P., Moran, K. M., Lemire, J. M., and Levin, M

Nature Communication 2017 Sep 25;8(1):587

​

HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a Nodal – and Lefty – asymmetric gene expression  - independent manner.

Pai VP, Willocq V, Pitcairn EJ, Lemire JM, Pare JF, Shi NQ, McLaughlin KA, Levin M.

Biology Open. 2017 Oct 15;6(10):1445-1457 (Cover)

​

Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis.

Pitcairn E, Harris H, Epiney J, Pai VP, Lemire JM, Ye B, Shi NQ, Levin M, McLaughlin KA.

Communicative & Integrative Biology 2017 May 10;10(3)

​

Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration and human mesenchymal cell differentiation.

Pai VP, Martyniuk CJ, Echeverri K, Sundelacruz S, Kaplan DL, Levin M. 

Regeneration 2016 Feb:3(1):3-25

​

Local and long-range endogenous resting potential gradients antagonistically regulate apoptosis and proliferation in the embryonic CNS.

Pai VP, Lemire JM, Lin G, Chen Y, Levin M.

International Journal of Developmental Biology 2015;59(7-9):327-40.

​

Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.

Pai VP, Lemire JM, Pare JF, Lin G, Chen Y, Levin M.

Journal of Neuroscience 2015 Mar 11;35(10):4366-85.

​

Type 7 serotonin receptor, 5-HT7, is essential in the mammary gland for regulation of mammary epithelial structure and function.

Pai VP, Hernandez LL, Stull MA, Horseman ND

BioMed Research International 2015;2015:364746

​

Neurally Derived Tissues in Xenopus Laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry.

Pai VP, Vandenberg LN, Blackiston D, Levin M.

Stem Cells International 2012;2012:353491

​

Molecular Bioelectricity in Developmental Biology: New Tools and Recent Discoveries (Cover)

Bioessays. 2012 Mar;34(3):205-17

​

Transmembrane Voltage Potential Controls Embryonic Eye Patterning in Xenopus laevis

Pai VP, Aw S, Shomrat T, Lemire JM, Levin M.

Development. 2012 Jan;139(2):313-23

​

Multiple Cellular Responses to Serotonin Contribute to Epithelial Homeostasis.

Pai VP, Horseman ND.

PLoS One. 2011 Feb 24;6(2):e17028.

​

Altered Serotonin Physiology in Human Breast Cancers favors Paradoxical Growth and Cell Survival.

Pai VP, Marshall AM, Hernandez LL, Buckley AR, Horseman ND.

Breast Cancer Research. 2009;11(6):R81.

​

In Vitro Multipotent Differentiation and Barrier Formation of a Human Mammary Epithelium.

Marshall AM, Pai VP, Sartor MA, Horseman ND.

Cell and Tissue Research. 2009 Feb;335(2):383-95 (Cover).

​

Biphasic Regulation of Mammary Epithelial Regulation by Serotonin Through Activation of Multiple Pathways.

Pai VP, Horseman ND.

Journal of Biological Chemistry. 2008 Nov 7;283(45):30901-10.

​

Mammary Gland Homeostasis Employes Serotonergic Regulation of Epithelial Tight Junctions.

Stull MA, Pai VP, Vomachka AJ, Marshall AM, Jacob GA, Horseman ND.

PNAS USA. 2007 Oct 16;104(42)