HCN2 rescues brain defects by enforcing endogenous voltage pre-patterns: Computationally modeling embryonic bioelectrics.

Pai, V. P., Peitak, A., Willocq V., Ye. B., Shi N-Q., and Levin, M

Nature Communication 2018 Mar 8;9(1):998

The brain is required for normal muscle and nerve patterning during early Xenopus development.

Herrera-Rincon, C., Pai, V. P., Moran, K. M., Lemire, J. M., and Levin, M

Nature Communication 2017 Sep 25;8(1):587

HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a Nodal – and Lefty – asymmetric gene expression  - independent manner.

Pai VP, Willocq V, Pitcairn EJ, Lemire JM, Pare JF, Shi NQ, McLaughlin KA, Levin M.

Biology Open. 2017 Oct 15;6(10):1445-1457 (Cover)

Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis.

Pitcairn E, Harris H, Epiney J, Pai VP, Lemire JM, Ye B, Shi NQ, Levin M, McLaughlin KA.

Communicative & Integrative Biology 2017 May 10;10(3)

Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration and human mesenchymal cell differentiation.

Pai VP, Martyniuk CJ, Echeverri K, Sundelacruz S, Kaplan DL, Levin M. 

Regeneration 2016 Feb:3(1):3-25

Local and long-range endogenous resting potential gradients antagonistically regulate apoptosis and proliferation in the embryonic CNS.

Pai VP, Lemire JM, Lin G, Chen Y, Levin M.

International Journal of Developmental Biology 2015;59(7-9):327-40.

Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.

Pai VP, Lemire JM, Pare JF, Lin G, Chen Y, Levin M.

Journal of Neuroscience 2015 Mar 11;35(10):4366-85.

Type 7 serotonin receptor, 5-HT7, is essential in the mammary gland for regulation of mammary epithelial structure and function.

Pai VP, Hernandez LL, Stull MA, Horseman ND

BioMed Research International 2015;2015:364746

Neurally Derived Tissues in Xenopus Laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry.

Pai VP, Vandenberg LN, Blackiston D, Levin M.

Stem Cells International 2012;2012:353491

Molecular Bioelectricity in Developmental Biology: New Tools and Recent Discoveries (Cover)

Bioessays. 2012 Mar;34(3):205-17

Transmembrane Voltage Potential Controls Embryonic Eye Patterning in Xenopus laevis

Pai VP, Aw S, Shomrat T, Lemire JM, Levin M.

Development. 2012 Jan;139(2):313-23

Multiple Cellular Responses to Serotonin Contribute to Epithelial Homeostasis.

Pai VP, Horseman ND.

PLoS One. 2011 Feb 24;6(2):e17028.

Altered Serotonin Physiology in Human Breast Cancers favors Paradoxical Growth and Cell Survival.

Pai VP, Marshall AM, Hernandez LL, Buckley AR, Horseman ND.

Breast Cancer Research. 2009;11(6):R81.

In Vitro Multipotent Differentiation and Barrier Formation of a Human Mammary Epithelium.

Marshall AM, Pai VP, Sartor MA, Horseman ND.

Cell and Tissue Research. 2009 Feb;335(2):383-95 (Cover).

Biphasic Regulation of Mammary Epithelial Regulation by Serotonin Through Activation of Multiple Pathways.

Pai VP, Horseman ND.

Journal of Biological Chemistry. 2008 Nov 7;283(45):30901-10.

Mammary Gland Homeostasis Employes Serotonergic Regulation of Epithelial Tight Junctions.

Stull MA, Pai VP, Vomachka AJ, Marshall AM, Jacob GA, Horseman ND.

PNAS USA. 2007 Oct 16;104(42)

Research Publications

- Claude Bernard -

“The joy of discovery is certainly the liveliest that the mind of man can ever feel”


Reviews and Book Chapters

Chapter 5: Bioelectric Control of Stem Cell Functions.

Pai VP, Levin M.

Book – ‘Stem Cells’ – Invited chapter – CRC Press, Science Publishers, Edenbridge Ltd. P.O.Box 699; Enfield, NH 03748, USA  Editors: Federico Calegari and Claudia Woskow February 7, 2014

Chapter 12: Mammary Gland Involution: Events, Regulation and Influences on Breast Diseases.

Pai VP, Horseman ND.

Book – ‘Endothelium and Epithelium: Composition, Functions and Pathology’ – Invited chapter – NOVA Science Publishers – February 2012 (Cover)

Intraluminal Volume Homeostasis: A Common Serotonergic Mechanism Among Diverse Epithelia.

Pai VP, Marshall AM.

Communicative & Integrative Biology. 2011 Sep;4(5):532-7.

Policy/Advocacy Articles 

Shaping the Future of Research: A Perspective from Junior Scientists.

McDOwell GS, Gunsalus KT, MacKellar DC, Mazzilli SA, Pai VP, Goodwin PR, Walsh EM, Robinson-Mosher, Bowman TA, Kraemer J, Erb ML, Schoenfeld E, Shokri L, Jackson JD, Islam A, Mattozzi MD, Kukenberg KA, Polka JK.

Version 2. F1000Res. 2014 Nov 28 [revised 2015 Jan 9];3:291

© 2018 by Vaibhav P. Pai

Allen Discovery Center

at Tufts University

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